OR6-001 - S100A12 as pro-inflammatory TLR4 ligand
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چکیده
منابع مشابه
OR6-001 - S100A12 as pro-inflammatory TLR4 ligand
Introduction The granulocyte-specific Ca-binding protein S100A12 is overexpressed during autoinflammation as well as other inflammatory conditions in humans and has been ascribed to the group of pro-inflammatory Damage Associated Molecular Pattern molecules (DAMPs). S100A12-levels in human serum reveal excellent correlation with patients’ inflammation state, which renders S100A12 a powerful bio...
متن کاملHexameric S100A12 is required for pro-inflammatory TLR4-signalling
Introduction The human granulocyte-specific Ca-binding protein S100A12 is particularily over-expressed in autoinflammatory diseases such as juvenile idiopathic arthritis (JIA) as well as other inflammatory conditions (i.e. infections, vasculitides) and has been ascribed to the group of pro-inflammatory damage associated molecular pattern molecules (DAMPs). In order to operate as DAMP, S100A12 r...
متن کاملS100A12 Suppresses Pro-inflammatory, but Not Pro-Thrombotic Functions of Serum Amyloid A
S100A12 is elevated in the circulation in patients with chronic inflammatory diseases and recent studies indicate pleiotropic functions. Serum amyloid A induces monocyte cytokines and tissue factor. S100A12 did not stimulate IL-6, IL-8, IL-1β or TNF-α production by human peripheral blood mononuclear cells but low amounts consistently reduced cytokine mRNA and protein levels induced by serum amy...
متن کاملExpression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis.
OBJECTIVES Infiltration of synovial tissue by neutrophils is crucial in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and seronegative arthritis (SA). Altered vascular function and endothelial activation are important in PsA. S100A12 (EN-RAGE) is secreted by activated granulocytes and binds to the receptor for advanced glycation end products, which induces nuclear factor (NF)-kappaB-depe...
متن کاملDeficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response
Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s1-a96